IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).

IGF-1 has been shown to promote proliferation of normal epithelial breast cells, and the IGF pathway has also been linked to mammary carcinogenesis in animal models.We comprehensively examined the association between common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to circulating IGF-I and IGFBP-3 levels and breast cancer

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Persistent Retinal Detachment in Retinoblastoma: The Challenges

Introduction.Retinoblastoma (RB) is the most common eye tumor in children.There have been significant improvements in treatment options targeting killing the tumor while also conserving the eye and attempting to conserve functional vision.Retinal detachment (RD) is not an uncommon event and compromises the vision and sometimes RB treatment.Material

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